Research progress in animal models of idiopathic pulmonary fibrosis
10.3969/j.issn.1005-4847.2025.05.013
- VernacularTitle:特发性肺纤维化动物模型的研究进展
- Author:
Lili TAN
1
;
Wei HUANG
;
Zixuan YANG
;
Pingxinyi QUE
;
Hong ZHANG
;
Songqi TANG
Author Information
1. 成都中医药大学药学院,成都 611130
- Publication Type:Journal Article
- Keywords:
idiopathic pulmonary fibrosis;
animal models;
phenotype
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(5):756-769
- CountryChina
- Language:Chinese
-
Abstract:
As a chronic progressive lung disease with poor prognosis,the pathogenesis of idiopathic pulmonary fibrosis(IPF)has not yet been clarified,and its treatment is still being explored.Animal models are important tools for studying the pathogenesis and therapeutic effects of diseases.Based on the similarity between animal models and human of IPF in terms of disease phenotype,this paper will review the research progress of IPF animal models in terms of the fibrosis mechanism induced by drugs and environmental factors,histopathological alterations,fibrosis stage,modelling time,etc.,and describe the advantages and disadvantages of different animal models,their characteristics and application profiles.
