Meta-analysis of the effects of different exercise interventions on head and neck cancer survivors
10.3760/cma.j.cn113030-20240617-00233
- VernacularTitle:不同运动干预对头颈部肿瘤患者影响的meta分析
- Author:
Tian TIAN
1
;
Yanlin LIU
;
Jie ZHANG
;
Juan WANG
Author Information
1. 甘肃中医药大学护理学院，甘肃 730000
- Publication Type:Journal Article
- Keywords:
Exercise;
Head and neck neoplasms;
Radiotherapy;
Chemotherapy;
Radiochemotherapy;
Fatigue;
Quality of life
- From:
Chinese Journal of Radiation Oncology
2025;34(2):128-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of exercise interventions on fatigue, quality of life and physical function in head and neck cancer patients receiving radiotherapy, chemotherapy and simultaneous radiochemotherapy.Methods:Embase, Web of Science, PubMed, Cochrane Library, Wanfang Database and CNKI, databases were searched with the timeframe from the establishment of the database to April 2024. Two researchers independently screened the literature, extracted information, assessed the quality of literature using the Physiotherapy Evidence Database (PEDro) scale, and statistically analyzed using RevMan 5.4 software. The main outcome indexes included cancer-related fatigue, 6 min walking distance (6MWD), body mass index (BMI) and fat-free mass.Results:A total of 12 articles involving 710 patients were included. PEDro scale scores were ranged from 5 to 8. Meta-analysis showed that exercise interventions relieved cancer-related fatigue [standard mean difference (SMD)=-0.90, 95% CI=-1.33 to -0.48, P<0.001], prolonged 6MWD (SMD=0.84, 95% CI=0.05 to 1.62, P=0.040), improved body composition, reduced BMI (SMD=-0.36, 95% CI=-0.66 to -0.70, P=0.020), and had no statistical significance for the increase of fat-free mass (SMD=0.32, 95% CI=-0.11 to 0.74, P=0.130). Subgroup analyses showed that taking aerobic combined with resistance training (SMD=-1.12, 95% CI=-1.46 to -0.79, I2=0%) and stretching (SMD=-0.90, 95% CI=-1.56 to -0.25, I2=75%) were more effective in relieving fatigue, aerobic combined with resistance training interventions (SMD=1.23, 95% CI= 0.28 to 2.18, I2=89%) was the most effective in extending the 6MWD. Patients receiving radiochemotherapy (SMD=-1.34, 95%CI=-1.67 to -1.01, I2=47%) and chemotherapy (SMD=-1.12, 95% CI=-1.80 to -0.45) showed more significant improvement in relieving cancer-related fatigue after exercise interventions. Those receiving radiochemotherapy (SMD=1.14, 95% CI=0.81 to 1.48, I2=0%) and chemotherapy (SMD=2.62, 95% CI=1.98 to 3.25) showed even better results in prolonging 6MWD after exercise interventions. Conclusion:Exercise intervention has a significant improvement effect on alleviating cancer-related fatigue, prolonging 6MWD, improving the quality of life and reducing BMI in head and neck cancer patients.
