Correlation between PCSK9,MIF and the degree of coronary artery stenosis in pa-tients with coronary heart disease
10.20039/j.cnki.1007-3949.2025.05.007
- VernacularTitle:血清PCSK9和MIF水平与冠心病患者冠状动脉病变程度的相关性
- Author:
Xin AN
1
;
Binbin FANG
;
Xiaolin YU
;
Fen LIU
;
Qian XIE
;
Xiaomei LI
;
Yining YANG
Author Information
1. 新疆医科大学第一附属医院心脏中心,新疆乌鲁木齐市 830054
- Publication Type:Journal Article
- Keywords:
proprotein convertase subtilisin/kexin type 9;
macrophage migration inhibitory factor;
Gensini score;
coronary heart disease
- From:
Chinese Journal of Arteriosclerosis
2025;33(5):419-426
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the relationship between serum levels of proprotein convertase subtilisin/kexin type 9(PCSK9),macrophage migration inhibitory factor(MIF)and the severity of coronary artery lesions in patients with coro-nary heart disease(CHD).Methods A cross-sectional study was conducted involving 139 patients with CHD and 69 control subjects who underwent coronary angiography during the same period,all of whom were admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from November 2023 to May 2024.Clinical data and coronary angiography results were collected,and the severity of coronary artery stenosis was quantitatively assessed using the Gensini score.Pa-tients with the Gensini scores＞0 were classified into three groups based on tertiles:the mild stenosis group(1～18 points,54 cases),the moderate stenosis group(19～36 points,54 cases),and the severe stenosis group(＞36 points,54 ca-ses).Serum levels of PCSK9 and MIF were measured by ELISA kit.Results Serum levels of PCSK9 and MIF were significantly higher in the CHD group than those in the control group(P＜0.05).Multivariable Logistic regression analy-sis revealed that high levels of serum PCSK9 and MIF were independent risk factors for CHD.Spearman correlation analy-sis showed that serum PCSK9 and MIF levels were positively correlated with Gensini score(rs=0.619 6 and r,=0.411 4,both P＜0.001).Further subgroup analysis showed that serum total cholesterol and low density lipoprotein cholesterol lev-els were significantly increased in patients with high-level PCSK9,while patients with high-level MIF had higher inflamma-tory coefficients such as systemic inflammatory response index(SIRI)and systemic immune-inflammation index(SII)(all P＜0.05).Conclusion Serum levels of PCSK9 and MIF are positively correlated with the severity of coronary artery stenosis.High levels of serum PCSK9 and MIF are independent risk factors for CHD.
