The progress of the role and mechanisms of circadian rhythm and clock gene in the development of atherosclerosis
10.20039/j.cnki.1007-3949.2025.05.001
- VernacularTitle:昼夜节律和时钟基因在动脉粥样硬化发生中的作用机制研究进展
- Author:
Wenlin LI
1
;
Sainan LI
1
;
Yao YANG
1
;
Qinan MA
1
;
Xiuqing HUANG
1
;
Lin DOU
1
;
Deping LIU
1
;
Jian LI
1
;
Tao SHEN
1
Author Information
1. 北京医院国家老年医学中心国家卫生健康委北京老年医学研究所国家卫生健康委老年医学重点实验室中国医学科学院老年医学研究院,北京市 100730
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
clock gene;
circadian rhythm;
lipid metabolism;
macrophage
- From:
Chinese Journal of Arteriosclerosis
2025;33(5):369-377
- CountryChina
- Language:Chinese
-
Abstract:
With the extension of the global population's lifespan and the increasingly severe aging problem,cardio-vascular diseases have become the leading cause of death among the elderly population.Most cardiovascular diseases orig-inate from the formation of atherosclerotic plaques.In addition to common risk factors such as dyslipidemia,diabetes,hy-pertension,smoking,and obesity,circadian rhythm disruption is also regarded as an important but often overlooked risk factor for atherosclerosis.The circadian rhythm is involved in regulating key physiological processes such as inflammation and metabolism,which in turn affect the pathological processes of arteriosclerosis and thrombosis.In this process,the key genes that maintain the stability of the circadian rhythm,namely clock gene,play a crucial role.Clock gene have an important role in the pathological mechanism of atherosclerosis,and they may become potential new targets for the preven-tion and treatment of atherosclerosis.This paper reviews the latest research progress on the mechanism of action of clock gene in the occurrence and development of atherosclerosis.These findings may provide new ideas for the diagnosis and treatment of atherosclerosis.
