Progress in role of mitochondrial transfer mediated by tunneling nano-tubes in ischemic stroke
10.3969/j.issn.1000-4718.2025.11.019
- VernacularTitle:隧道纳米管介导的线粒体转移在缺血性卒中的研究进展
- Author:
Jingjing KANG
1
;
Xiang CAO
Author Information
1. 黄河科技学院医学院生化教研室,河南 郑州 450063
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
tunneling nanotubes;
mitochondrial transfer;
stem cells;
astrocytes
- From:
Chinese Journal of Pathophysiology
2025;41(11):2237-2242
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke(IS),caused by the interruption of cerebral blood flow,results in localized ischemia and hypoxia in the brain tissue.Its pathophysiological mechanisms are complex,involving disturbances in energy metabo-lism,oxidative stress,inflammation,and apoptosis.As the cell's powerhouse,mitochondria play a critical role in IS,and their dysfunction exacerbates neuronal injury.In recent years,tunneling nanotubes(TNTs),a novel form of intercellular communication,have gained increasing attention for their role in mediating the intercellular transfer of functional mito-chondria.Studies have shown that both stem cells and astrocytes can transfer healthy mitochondria to damaged neurons via TNTs,thereby restoring energy metabolism,reducing apoptosis,and alleviating neurological deficits.This review summa-rizes the current research on the mechanisms and biological functions of TNT-mediated mitochondrial transfer and discuss-es its potential therapeutic applications in IS,aiming to provide insight into IS treatment strategies.
