Progress in effects and mechanisms of exercise preconditioning in im-proving outcomes after ischemic stroke
10.3969/j.issn.1000-4718.2025.00.019
- VernacularTitle:运动预适应改善缺血性脑卒中预后及其机制的研究进展
- Author:
Peishan CHEN
1
;
Lin ZHU
;
Xiaoguang LIU
;
Huan WANG
Author Information
1. 广州体育学院,广东 广州 510500
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
ischemic tolerance;
exercise preconditioning;
physical activity
- From:
Chinese Journal of Pathophysiology
2025;41(11):2256-2264
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is one of the leading causes of mortality and disability,and it particularly inflicts brain damage through various mechanisms.However,there is a significant gap in the availability of specific drugs for the treatment of ischemic stroke.Numerous studies have demonstrated that exercise preconditioning can provide protective ef-fects against ischemic stroke through complex mechanisms.In this review,we aim to summarize the amount of exercise re-quired to induce exercise preconditioning and its potential mechanisms for improving outcomes in ischemic stroke.The fol-lowing benefits of exercise preconditioning have been identified in relation to ischemic stroke:(1)reduction of cerebral edema and infarct size,while promoting angiogenesis;(2)preservation of the integrity of the blood-brain barrier,reduc-tion of apoptosis,and mitigation of neurological damage;(3)inhibition of glutamate overactivation,alleviation of oxida-tive stress,and improvement of the inflammatory response.Ultimately,exercise preconditioning mitigates the damage caused by ischemic stroke through these pathways.
