Progress in exercise factors differentially mediating integrated stress re-sponse to alleviate nonalcoholic fatty liver disease and cardiovascular dis-eases
10.3969/j.issn.1000-4718.2025.11.023
- VernacularTitle:运动因素差异介导整合应激反应缓解非酒精性脂肪性肝病和心血管疾病的研究进展
- Author:
Mingchen ZHANG
1
;
Minghua CHEN
;
Yushuang DUAN
;
Zhongguang SUN
Author Information
1. 山东第二医科大学康复医学院,山东 潍坊 261053;山东省临沂市人民医院康复医学科,山东 临沂 276003
- Publication Type:Journal Article
- Keywords:
integrated stress response;
aerobic exercise;
cardiovascular diseases;
nonalcoholic fatty liver disease
- From:
Chinese Journal of Pathophysiology
2025;41(11):2265-2271
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease(CVD)is the leading cause of death among patients with non-alcoholic fatty liver disease(NAFLD),which is also recognized as an independent risk factor for CVD.Exercise has emerged as a prom-ising therapeutic approach that can ameliorate a range of conditions,including those related to the cardiovascular and en-docrine systems.Recent research has highlighted the critical role of the integrated stress response(ISR)in the mecha-nisms and manifestations of these diseases.Notably,exercise influences ISR protein markers,regulates protein expres-sion,alleviates stress levels,and ultimately impacts disease onset and progression.Current studies suggest that the effects of ISR modulation through various exercise conditions differ for the heart and liver.However,evidence indicates that un-der specific circumstances,exercise can engage the PERK and GCN2 pathways to inhibit the ISR,thereby regulating glu-cose and lipid metabolism,apoptosis,and endoplasmic reticulum stress.These actions contribute to the protection of car-diac and hepatic function,ultimately improving outcomes in CVD and NAFLD.This review aims to provide novel insights and a theoretical foundation for the role of exercise in mitigating the onset of NAFLD,CVD,and related disorders.
