Advances in homeostasis of hepatic vascular microenvironment in chronic liver diseases
10.3969/j.issn.1000-4718.2025.11.021
- VernacularTitle:肝脏血管微环境稳态在慢性肝脏疾病中的研究进展
- Author:
Jing ZHANG
1
;
Qiuping CHEN
1
;
Jibin LIU
1
;
Quansheng FENG
1
Author Information
1. 成都中医药大学基础医学院,四川 成都 611137
- Publication Type:Journal Article
- Keywords:
chronic liver disease;
hepatic vascular microenvironment;
homeostatic imbalance;
microcircula-tory disorders;
mechanical force
- From:
Chinese Journal of Pathophysiology
2025;41(11):2250-2255
- CountryChina
- Language:Chinese
-
Abstract:
The hepatic vascular microenvironment(HVM)plays a pivotal role in maintaining liver function homeostasis,including metabolism,detoxification,and coagulation.The maintenance of HVM homeostasis is governed by an intricate interplay of mechanical forces,chemical signals,and neuroelectrophysiological conduction.Recent studies have shown that an imbalance in HVM promotes the progression of chronic liver disease(CLD),which is characterized by sinusoidal capillarization,vascular deformation and remodeling,and the arterialization of blood supply.This review sum-marizes the dynamic regulatory mechanisms that underpin HVM in physiological conditions,and the primary pathological manifestations observed at various stages of CLD progression,aiming to provide a robust framework for the development of therapeutic strategies targeting HVM homeostatic imbanlance in CLD.
