Application of phenolic adhesive slurry in animal models of gynecological diseases
10.3969/j.issn.1005-4847.2025.05.014
- VernacularTitle:苯酚胶浆在妇科疾病动物模型中的应用
- Author:
Guanglong WANG
1
;
Suo ZHANG
1
Author Information
1. 内蒙古医科大学中医学院,呼和浩特 010059
- Publication Type:Journal Article
- Keywords:
phenolic paste;
gynecological diseases;
animal models;
TCM syndrome and signs
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(5):770-778
- CountryChina
- Language:Chinese
-
Abstract:
The phenol glue modeling method is a widely used modeling technique in animal experimental models of gynecological diseases.Phenol glue is injected into the rat uterus as an adhesive agent,causing chemical burns to the pelvic organ tissues,to construct animal models of pelvic inflammatory disease,cervicitis,endometritis,salpingitis,vaginitis,and other gynecological diseases.The burns induce hyperemia,edema,inflammatory exudation,inflammatory adhesions,and blockages,leading to chronic inflammation.The corrosive and adhesive properties of phenol paste are also used to create animal models replicating gynecological diseases in traditional Chinese medicine,based on the syndrome of dampness and blood stasis.The successful establishment of the phenol glue model provides a crucial experimental basis for studying the pathological mechanisms and treatment method of gynecological diseases.
