The effect of different RLNLN dissection on the short-term efficacy,serum TREM-1,TRAP1 levels,and quality of life in patients with esophageal cancer undergoing thoracoscopic radical resection
10.3969/j.issn.1005-6483.20240814
- VernacularTitle:食管癌胸腔镜根治术中不同喉返神经旁淋巴结清扫对近期疗效、血清髓系细胞触发受体-1、肿瘤坏死因子受体相关蛋白-1水平及生存质量的影响
- Author:
Yuhui YUN
1
;
Xiang JI
1
;
Guoliang HAN
1
;
Wei GUO
1
Author Information
1. 710038 西安,空军军医大学第二附属医院胸腔外科
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
thoracoscopic radical surgery;
paralaryngeal lymph node of the recurrent laryngeal nerve;
complication;
recurrence
- From:
Journal of Clinical Surgery
2025;33(5):482-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of different lymph node dissection(RLNLN)around the recurrent laryngeal nerve(RLN)on the clinical efficacy of esophagectomy(EC)with thoracoscopic radical surgery.Methods Ninety-eight EC patients were selected from 2022-01 to 2022-10 in our hospital and divided into the control group and the study group,each with 49 cases,using simple randomization method.Both groups underwent EC thoracoscopic radical surgery,with conventional RLNLN clearance in the control group and modified RLNLN clearance in the study group.The operation and postoperative recovery of the two groups were compared,as well as myeloid triggered receptor-1(TREM-1),tumor necrosis factor receptor-associated protein-1(TRAP1),and complications before and after the operation,and the recurrence rate and survival rate of the two groups were counted at 1 year after the operation.Results The RLNLN dissection time in the study group was(11.93±3.57)minutes,which was shorter than that in the control group(17.15±4.28)minutes.The number of RLNLN dissections on both sides was(7.19±1.24),which was higher than that in the control group(5.56±1.10),and the differences were statistically significant(P＜0.05).Three and seven days after surgery,the CD3+,CD4+/CD8+of the study group were higher than those of the control group,while CRP,PCT,TREM-1,and TRAP1 were lower than those of the control group,and the differences were statistically significant(P＜0.05).The postoperative complication and recurrence rates in the study group were 4.08％(2/49)and 10.87％(5/46),respectively,which were lower than the control group[18.37％(9/44),29.55％(13/44)].Conclusion Thoracoscopic radical resection of esophageal cancer with modified RLNLN dissection can can enhance the effect of lymph node clearance,down-regulate the expression of TREM-1 and TRAP1,reduce the inflammatory response of the body,regulate the immune function,reduce the risk of complications and recurrence,and improve the quality of life.
