The research advances of transcription factor EB in the regulation of lipid metabolism
10.20039/j.cnki.1007-3949.2025.05.002
- VernacularTitle:转录因子EB在调控脂质代谢中的研究进展
- Author:
Huijuan LI
1
;
Yun WANG
1
;
Tongdong KUANG
1
;
Yuncheng LYU
1
Author Information
1. 桂林医学院广西糖尿病重点实验室医学重点实验室,广西桂林市 541199
- Publication Type:Journal Article
- Keywords:
transcription factor EB;
lipid metabolism;
metabolic associated fatty liver disease;
atherosclerosis;
obesity
- From:
Chinese Journal of Arteriosclerosis
2025;33(5):378-384,394
- CountryChina
- Language:Chinese
-
Abstract:
Transcription factor EB(TFEB),which belongs to the microphthalmia/transcription factor E(MiTF/TFE)family,is mainly functioned as regulator involved in regulating lysosomal function and autophagy.It plays an im-portant role in lipid metabolism via modulating lysosomal lipid degradation,mitochondrial β-oxidation of fatty acid,and in-tracellular cholesterol efflux.TFEB inhibits the development of metabolic associated fatty liver disease(MAFLD)and o-besity by regulating the autophagy and the expression of lipid metabolism-related genes.Additionally,it prevents the for-mation of foam cell from macrophages and vascular smooth muscle cells by restraining lipid accumulation,thereby attenua-ting the progression of atherosclerosis.TFEB promotes lipophagy to relieve lipid accumulation and lipid accumulation-in-duced insulin resistance,and β-cell failure,deferring diabetes-related lipid metabolic disorders.In summary,TFEB plays a key role in lipid metabolism and associated lipid disorder diseases,and serves as a potential clinical target to correct lipid dysmetabolism in vivo.
