Research progress in the use of oncolytic viruses to induce tumor immunogenic cell death
10.3969/j.issn.1671-7856.2025.10.015
- VernacularTitle:溶瘤病毒在肿瘤免疫原性细胞死亡中的研究进展
- Author:
Sibo ZHANG
1
;
Lifang JIA
;
Lulu LI
;
Jing WANG
;
Kaiyang LIU
Author Information
1. 河北北方学院生命科学研究中心,河北 张家口 075000
- Publication Type:Journal Article
- Keywords:
oncolytic virus;
immunogenic cell death;
damage-associated molecular patterns;
research progress
- From:
Chinese Journal of Comparative Medicine
2025;35(10):149-161
- CountryChina
- Language:Chinese
-
Abstract:
Immunogenic cell death(ICD)is a form of cell death that can activate the immune system,especially in the treatment of cancer.ICD can enhance the recognition of tumors by the immune system and the release of damage associated molecular patterns(DAMPs),to achieve tumor cell death.Oncolytic viruses(OVs)can selectively infect and kill tumor cells without damaging normal cells.OVs are type Ⅱ ICD inducers that induce ICD in tumor cells by targeting the endoplasmic reticulum.Here,we review the characteristics of ICD and the mechanism of ICD induction by OVs.We also review the latest clinical progress involving ICD and discuss future treatment strategies for tumors.
