Research advances in roles of extrasynaptic GABAA receptors in postpartum depression and premenstrual syndrome
10.3867/j.issn.1000-3002.2025.08310
- VernacularTitle:突触外GABAA受体在产后抑郁症和经前综合征中的作用研究进展
- Author:
Xiaoli LIU
1
;
Hongbo WANG
;
Gang YU
;
Ruibin SU
Author Information
1. 烟台大学药学院,山东 烟台 264005;军事医学研究院神经精神药理学北京市重点实验室,北京 100850
- Publication Type:Journal Article
- Keywords:
extrasynaptic γ-aminobutyric acid type A receptors;
δ subunit;
postpartum pepression;
premenstrual syndrome
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(6):462-468
- CountryChina
- Language:Chinese
-
Abstract:
Extrasynaptic γ-aminobutyric acid type A(GABAA)receptors are a class of inhibitory neurotransmitter receptors that are distributed in non-synaptic structures such as cell bodies and dendrites.Extrasynaptic GABAA receptors are heteropentamers usually containing δ-subunit.Changes of δ-subunit expressions can be observed in model animals of postpartum depression and premenstrual syndrome,and δ-/-or δ+/-mice exhibit behavioral phenotypes of postpartum depression,suggesting that extrasynaptic GABAA receptors are involved in the pathogenesis of related diseases.The present review is concerned with the relationship between extrasynaptic GABAA receptors and postpartum depression as well as premenstrual syndrome in general,and the advances in research on drugs targeting extrasynaptic GABAA receptors for the treatment of these two conditions in particular.The article highlights the value of extrasynaptic GABAA receptors as a therapeutic target for female mood disor-ders,and may provide a reference for the development and application of related drugs.
