Risk factors of osteoporosis and its correlation with lipid metabolism in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.06.007
- VernacularTitle:2型糖尿病患者发生骨质疏松的危险因素及与脂代谢相关性的研究
- Author:
Jun LI
1
;
Juan HUANG
1
;
Weiwei LI
1
Author Information
1. 400030 重庆市沙坪坝区人民医院全科医学科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Osteoporosis;
Risk factors;
Blood lipid metabolism;
Bone mineral density
- From:
Chinese Journal of Diabetes
2025;33(6):435-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors of osteoporosis and its correlation with lipid metabolism in patients with type 2 diabetes mellitus(T2DM).Methods A total of 400 patients with T2DM hospitalized in the Department of General Medicine of our hospital were enrolled in this study from May 2020 to June 2023 and divided into T2DM simple group(n=200)and OP combined group(OP group,n=200)according to whether they had OP.DBP,SBP,FPG,HbA1c,TC,TG,HDL-C,LDL-C,calcium(Ca),and phosphorus(P)were compared between the two groups.Bone mineral density(BMD)of lumbar spine and left femoral neck were detected by bone densitometry,and osteocalcin(OC)and calcitonin(CT)were detected by RIA method.Results Compared with T2DM group,the TC,LDL-C,and SBP increased(P<0.05),while Ca,P,OC,and CT decreased in OP group(P<0.05).Pearson correlation analysis showed that Ca,P,OC and CT were negatively correlated with TC and LDL-C(P<0.05).Logistic stepwise regression analysis showed that SBP,TC,LDL-C,Ca,P,OC and CT were the risk factors for OP in T2DM patients.Conclusions SBP,TC,LDL-C,Ca,P,OC and CT are risk factors for OP in patients with T2DM,Ca,P,OC and CT are negatively correlated with TC and LDL-C.
