Effect of GLP-1R gene polymorphism on the efficacy of Lirglutide in type 2 diabetes mellitus patients with metabolic associated fatty liver disease
- VernacularTitle:胰高血糖素样肽1受体基因多态性对利拉鲁肽治疗2型糖尿病合并代谢相关脂肪性肝病疗效影响的研究
- Author:
Beibei WANG
1
;
Yongli YAO
1
;
Lingling ZHAO
1
;
Shuqiong WANG
1
;
Kang SONG
1
;
Yanan LI
1
;
Xiaoxia FAN
1
;
Lijun LIN
1
;
Yanling XIE
1
;
Yanping JIANG
1
;
Jingyuan WANG
1
;
Ying QU
1
;
Wei LUO
1
Author Information
- Publication Type:Journal Article
- Keywords: Diabetes mellitus,type 2; Metabolically related fatty liver disease; Glucagon-like peptide-1 receptor; rs3765467; Lirglutide
- From: Chinese Journal of Diabetes 2025;33(6):414-418
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effect of the rs3765467 polymorphism of glucagon-like peptide-1 receptor(GLP-1R)gene on the efficacy of Liraglutide(Lir)in patients with type 2 diabetes mellitus(T2DM)and metabolic associated fatty liver disease(MAFLD).Methods A total of 281 patients with T2DM from May 2022 to May 2023 were selected,including 125 patients with simple T2DM(T2DM group)and 156 patients with T2DM combined with MAFLD(T2DM+MAFLD group).120 healthy individuals during the same period were selected as the control(NC)group.The related indexes of glucose and lipid metabolism were detected.The polymorphism of GLP-1R gene rs3765467 was detected.Results BMI,FPG,HbA1c,HOMA-IR and TG in each group increased in turn(P<0.05),while the distribution frequency of genotype GG and allele G decreased in turn(P<0.05).TC and LDL-C in T2DM and T2DM+MAFLD groups were higher than those in NC group(P<0.05).TC and TG levels in genotype GA/AA patients were significantly higher than those in genotype GG patients(P<0.05).Compared with before treatment,the levels of BMI,FPG,HbA1c,HOMA-IR,TC,TG and LDL-C in T2DM patients with MAFLD were significantly decreased after Lir treatment(P<0.05).There was no significant difference in BMI and related indexes of glucose and lipid metabolism in GG and GA/AA patients before and after Lir treatment(P>0.05).Conclusions The distribution frequency of GG and G allele at rs3765467 of GLP-1R gene is reduced in T2DM patients with MAFLD.The carrying of allele A was associated with increased TC and TG levels,but did not affect the efficacy of Lir in reducing weight and improving glycolipid metabolism.
