Research Progress of Flavonoids Derived from Forsythia against Respiratory Viruses
10.14148/j.issn.1672-0482.2025.1573
- VernacularTitle:连翘来源的黄酮化合物抗呼吸道病毒的研究进展
- Author:
Jiaqing LIU
1
;
Wei HONG
;
Yingjie QING
Author Information
1. 南京中医药大学药学院,江苏 南京 210023
- Publication Type:Journal Article
- Keywords:
forsythia;
flavonoids;
respiratory viruses;
viral targets;
immune regulation;
inflammation suppression;
post-viral syn-drome
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(11):1573-1584
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory viruses,characterized by high mutation rates and strong immune evasion,remain a significant global public health challenge.Natural products have gained increasing attention due to their multi-target modulation and high safety profiles,dem-onstrating unique advantages in antiviral,anti-inflammatory,and immunoregulatory applications.Forsythia,a deciduous shrub of the Oleaceae family,possesses medicinal value in nearly all its parts,with flavonoids being among its most prominent bioactive compo-nents.This review provides a comprehensive summary of the botanical characteristics and traditional medicinal uses of Forsythia,the composition and structural classification of flavonoids from different parts of the plant,and its clinical applications.Building on the"holistic view"of traditional Chinese medicine,this review primarily discusses the antiviral mechanisms of Forsythia-derived flavo-noids in four key aspects:viral targeting,immune regulation,inflammation suppression,and post-viral syndrome.Additionally,it ana-lyzes its clinical application advantages and translational strategies,providing a basis for further development of new natural products and therapeutic drugs in clinical practice.
