Research Progress on the Regulation of Respiratory Syncytial Virus Infection-Related Signaling Pathways by Chinese Medicine
10.14148/j.issn.1672-0482.2025.1503
- VernacularTitle:中药调控呼吸道合胞病毒感染相关信号通路的研究进展
- Author:
Yiting JIANG
1
;
Feng HE
;
Miao FENG
;
Sen LI
;
Dingding CAO
;
Hailan YAO
Author Information
1. 北京大学首都儿科研究所教学医院,北京 100020;首都医科大学附属首都儿童医学中心,首都儿科研究所,北京 100020
- Publication Type:Journal Article
- Keywords:
Chinese medicines;
respiratory syncytial virus;
signal pathway;
research progress
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(11):1503-1511
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory syncytial virus(RSV)infection is a major respiratory disease threatening the health of infants and immuno-compromised populations worldwide,with no specific therapeutic drugs available.Traditional Chinese medicine(TCM)has shown unique advantages of multi-target and multi-pathway in the prevention and treatment of RSV infection,and its mechanism is closely re-lated to the regulation of cellular signaling pathways.This article systematically reviews the research progress of TCM including mono-mer components and compound prescriptions in intervening RSV infection through nuclear factor-κB(NF-κB),Janus kinase/signal transducer and activator of transcription(JAK/STAT),phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),mitogen-activated protein kinase(MAPK),nuclear factor E2-related factor 2/heme oxygenase-1(Nrf2/HO-1)and other signaling pathways.Current re-search still has problems such as insufficient analysis of pathway synergy mechanisms,unclear material basis of compounds,and single technical means.Future studies should focus on cross-talk of multiple pathways,identification of active component groups of TCM,and research on"syndrome-type-pathway"association,combined with cutting-edge technologies such as network pharmacology and or-ganoid models,so as to provide a scientific basis for the mechanism and clinical transformation of TCM against RSV infection.
