Observation on the therapeutic effects of ultrasound assisted administration of nusinersen in spinal muscular atrophy patients with scoliosis
10.3969/j.issn.1004-1648.2025.03.009
- VernacularTitle:超声引导下鞘内注射诺西那生钠治疗合并脊柱侧弯的脊髓性肌萎缩症的疗效观察
- Author:
Ruo ZHANG
1
;
Qi RU
1
;
Xiaoguang LI
1
Author Information
1. 266000 青岛,山东大学齐鲁医院(青岛)超声科
- Publication Type:Journal Article
- Keywords:
spinal muscular atrophy;
scoliosis;
ultrasound;
nusinersen;
ultrasound localization
- From:
Journal of Clinical Neurology
2025;38(3):203-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the therapeutic effects of ultrasound(US)assisted administration of nusinersen in spinal muscular atrophy(SMA)patients with scoliosis.Methods The clinical data of 7 SMA patients with scoliosis treated with US assisted administration of nusinersen were retrospectively reviewed.The locating time,level of puncture points,puncture time,the number of puncture attempts,pain scores and adverse events were recorded.Meantime,the learning curve(LC)of US assisted administration of nusinersen for SMA patients with scoliosis was analyzed using cumulative sum(CUSUM).Results Thirty-one procedures were performed on 7 SMA patients with scoliosis.The success rate was 100％.The locating time was 11.9(5.1,15.4)min,the puncture time was 12.6(6.0,16.9)min,the number of puncture attempts were 2.0(1.0,3.0),the pain scores were 2.1(1.0,3.0).During the follow-up period of six months,only 1 patient had dizziness and soreness of waist.No serious adverse events were observed.The locating time,puncture time and the number of puncture attempts decreased as the number of procedures increased.Evaluation of the CUSUM curve revealed that 14 cases were needed to achieve proficiency.Conclusion US assisted administration of nusinersen is a valid and safe technique,deserving further clinical promotion and application on SMA patients with scoliosis.
