Natural Product Intervention Strategies for High-Incidence Respiratory Viral Infections
10.14148/j.issn.1672-0482.2025.1541
- VernacularTitle:高发呼吸道病毒感染的天然产物干预策略
- Author:
Yancheng YU
1
;
Ning DING
;
Zonghao ZHAO
;
Nianguang LI
;
Peng CAO
Author Information
1. 南京中医药大学药学院,江苏 南京 210028
- Publication Type:Journal Article
- Keywords:
natural products;
respiratory viruses;
antiviral;
lead compounds;
target mechanisms
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(11):1541-1559
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory viral infections pose serious threats to human health,particularly highlighted by recent pandemics caused by influenza viruses and coronaviruses.Natural products,characterized by their structural diversity and unique biological activities,offer promising resources for antiviral drug development.This review systematically summarizes the biological features,infection mechanisms,and antiviral targets of five major respiratory viruses—namely influenza virus,coronavirus,respiratory syncytial virus,human rhinovirus,and human metapneumovirus.It highlights recent progress in the discovery of antiviral natural products,including their chemical structures,mechanisms of action,and in vitro/in vivo activities.Many of these compounds not only inhibit viral entry and replication but also modulate host immune responses,exhibiting broad-spectrum,low-toxicity,and high-efficiency potential.This work aims to provide theoretical references and lead compound resources for future antiviral drug discovery and mechanistic re-search.
