Exploring the Potential of Intervening Glycoconjugate in Traditional Chinese Medicine against Respira-tory Viral Infections Based on Glycosylation Patterns
10.14148/j.issn.1672-0482.2025.1531
- VernacularTitle:基于糖基化模式探讨中药干预糖缀合物抗呼吸道病毒感染的潜力
- Author:
Yue KANG
1
;
Zhaowei ZHANG
;
Peng CAO
;
Jianjian JI
Author Information
1. 南京中医药大学药学院,江苏 南京 210023
- Publication Type:Journal Article
- Keywords:
respiratory viral infection;
glycoconjugate;
glycosylation modification;
traditional Chinese medicine
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(11):1531-1540
- CountryChina
- Language:Chinese
-
Abstract:
The high pathogenicity and mortality of respiratory viral infections pose a significant clinical burden.Due to the high de-gree of variability of viral proteins,some current targeted drugs are highly susceptible to drug resistance,and there is an urgent need for the development of effective therapeutic strategies.Glycoconjugates are widely distributed in hosts and viruses,and participate in host-virus interactions,viral replication,innate and adaptive immunity,etc.Aberrant glycosylation is involved in the pathogenesis of a vari-ety of diseases,and anti-respiratory viral strategies targeting glycosylation have the advantages of high specificity,low drug resistance,and broad-spectrum.In recent years,traditional Chinese medicines(TCMs)have shown unique potential in intervening in glycosylation-related antiviral fields due to their multi-target regulatory properties.The aim of this paper is to focus on the biological functions of glycosylation modifications,the research progress of virus infection and potential TCM monomers targeting glycosylation,which not only reveals the scientific connotation of TCM regulation of glycosylation,but also provides a natural molecular library for the development of novel antiviral strategies based on glycosylation intervention.In the future,it is necessary to further combine the tech-niques of glycomics and structural biology to elucidate the precise mechanism of spatial and temporal dynamics of TCM monomers in regulating glycosylation,and to promote the modernization of TCM.
