Research on the correlation between Klotho gene and protein and vascular cognitive dysfunction
10.3969/j.issn.1004-1648.2025.03.012
- VernacularTitle:Klotho基因及蛋白与血管性认知功能障碍相关性的研究
- Author:
Yu SHANG
1
;
Jiuling LIU
1
;
Min YE
1
Author Information
1. 210019 南京医科大学附属明基医院神经内科
- Publication Type:Journal Article
- Keywords:
Klotho gene;
Klotho protein;
vascular cognitive impairment
- From:
Journal of Clinical Neurology
2025;38(3):217-221
- CountryChina
- Language:Chinese
-
Abstract:
The number of patients with vascular cognitive impairment(VC I)is increasing year by year,and its incidence rate is second only to that of Alzheimer's disease(AD),becoming the second leading cause of dementia.It should be noted that,VCI is a disease that can be controlled by early diagnosis and timely treatment,and It is even a disease that can achieve clinical cure.Therefore,an in-depth exploration of the pathogenesis of VCI,as well as the development of effective early diagnostic and preventive strategies,is not only of significant clinical guidance importance but also holds profound social value.The Klotho gene,an anti-aging gene,is primarily expressed in the brain's choroid plexus and kidneys.The Klotho protein it encodes not only has anti-aging and longevity-extending functions but is also closely associated with cognitive function.Current research has revealed a strong connection between Klotho protein levels and vascular cognitive impairment induced by ischemic stroke,suggesting that Klotho protein could serve as an important biomarker for predicting vascular cognitive impairment after ischemic stroke.This article aims to comprehensively summarize the latest research progresses on the Klotho gene and its polymorphisms,as well as the Klotho protein and cognitive impairment following ischemic stroke,both domestically and internationally,in the hope of providing a solid theoretical foundation and reference for further research in this field.
