Research progress on the pathogenesis and clinical features of myelin oligodendrocyte glycoprotein antibody and N-methyl-D-aspartate receptor antibody overlap syndrome
10.3969/j.issn.1004-1648.2025.03.010
- VernacularTitle:髓鞘少突胶质细胞糖蛋白抗体和N-甲基-D-天冬氨酸受体抗体重叠综合征的发病机制和临床特征研究进展
- Author:
Heng YUE
1
;
Xia CAI
Author Information
1. 046000 长治医学院第一临床学院
- Publication Type:Journal Article
- Keywords:
myelin oligodendrocyte glycoprotein;
anti-N-methyl-D-aspartate receptor;
syndrome;
research progress
- From:
Journal of Clinical Neurology
2025;38(3):207-212
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing recognition of myelin oligodendrocyte glycoprotein(MOG)antibody and N-methyl-D-aspartate receptor(NMDAR)antibody overlap syndrome(MNOS),the hypothesis on the mechanism of double antibody positivity has gradually been refined.It is believed that both antibodies can appear simultaneously or successively.When they appear successively,the disease spectra mediated by the two antibodies overlap,leading to the diversity of such disease syndromes and making clinical identification challenging.Initially,NMDAR-IgG often appears first,NMDAR encephalitis(NMDARE)is diagnosed primarily.Later,when the disease recurs or exhibits clinical features of MOG-IgG associated disorders,it suggests the coexistence of both antibodies.NMDARE patients with MOG-IgG positivity tend to have a younger age of onset,are more prone to recurrence,are more likely to have prodromal infection,are highly sensitive to hormones,and rarely have comorbidities with tumors,indicating a good prognosis.This may suggest a new disease entity.This article summarizes the current research progress on the pathophysiology and clinical features of MNOS.
