Research progress in the role of cannabidiol in drug addiction
10.3969/j.issn.1671-7856.2025.10.013
- VernacularTitle:大麻二酚在药物成瘾中的作用及研究进展
- Author:
Xiong LI
1
;
Jiameng DING
1
;
He YAN
1
;
Genmeng YANG
1
;
Xiao MA
1
;
Shijun HONG
1
;
Dongxian ZHANG
1
Author Information
1. 昆明医科大学法医学院,国家卫生健康委员会毒品依赖和戒治重点实验室,昆明 650500
- Publication Type:Journal Article
- Keywords:
cannabidiol;
drug addiction;
reward effect;
drug seeking;
narcotics
- From:
Chinese Journal of Comparative Medicine
2025;35(10):124-139
- CountryChina
- Language:Chinese
-
Abstract:
Drug addiction is a serious public health problem worldwide,for which there are currently no established therapeutic medications.Since the legalization of cannabis and the approval of cannabidiol(CBD)by the US Food and Drug Administration,its therapeutic potential for the treatment of substance abuse has been widely explored.Numerous studies have shown that CBD can reduce drug reward in animal models of addiction such as self-administration,conditioned positional preference,and intracranial self-stimulation.CBD can also reduce withdrawal symptoms from substances such as amphetamines,opioids,cocaine,marijuana,alcohol,and nicotine.The mechanisms by which CBD modulates drug addiction,however,are complex and understudied.Here we review studies of CBD related to addictive drugs to clarify the regulatory mechanisms of CBD in drug addiction and provide references for related studies on substance abuse.
