Predictive value of serum Ficolin-3 and proprotein convertase subtilisin/kexin type 9 for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
10.3969/j.issn.1004-1648.2025.03.004
- VernacularTitle:血清纤维凝胶蛋白-3、前蛋白转化酶枯草溶菌素9对动脉瘤性蛛网膜下腔出血后迟发性脑缺血的预测价值
- Author:
Yehua JIA
1
;
Hongyi ZHANG
1
;
Jian HAN
1
Author Information
1. 063000 唐山中心医院神经外科
- Publication Type:Journal Article
- Keywords:
Ficolin-3;
proprotein convertase subtilisin/kexin type 9;
aneurysmal subarachnoid hemorrhage;
delayed cerebral ischemia;
predictive value
- From:
Journal of Clinical Neurology
2025;38(3):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the predictive value of serum Ficolin-3 and proprotein convertase subtilisin/kexin type 9(PCSK9)for delayed cerebral ischemia(DCI)after aneurysmal subarachnoid hemorrhage(aSAH).Methods From January 2020 to November 2024,110 patients with aSAH who visited our hospital were used as the study group,and another 110 healthy individuals who underwent physical check-up at our hospital were used as the control group.Complying with the diagnostic criteria of DCI,patients were grouped into DCI group(n=41)and non DCI group(n=69).ELISA method was used to detect serum Ficolin-3 and PCSK9.Multivariate Logistic regression was used to analyze the factors influencing the occurrence of DCI in aSAH patients.ROC curves were used to analyze the predictive efficacy of serum Ficolin-3 and PCSK9 for DCI in aSAH patients.Results Compared with the control group,the serum Ficolin-3 in the study group was prominently lower,and the PCSK9 was prominently higher(all P＜0.05).Compared with the non DCI group,the proportion of improved Fisher grading≥3,Hunt-Hess grading≥3,and serum PCSK9 were prominently higher in DCI group,while serum Ficolin-3 was prominently lower(all P＜0.05).Improved Fisher grading ≥ 3,Hunt-Hess grading ≥ 3,and elevated serum PCSK9 were all risk factors for DCI after aSAH(all P＜0.05),while elevated serum Ficolin-3 was a protective factor(P＜0.05).The area under curve(AUC)of serum Ficolin-3 and PCSK9 in predicting DCI after aSAH was 0.796 and 0.828,respectively,the AUC of combined prediction was 0.908,the combined predictive performance of the two indicators was better than that of a single indicator(Zcombination-Ficolin-3=2.375,Zcombination-PCSK9=2.330;P=0.018,P=0.020).Conclusions Serum Ficolin-3 is decreased and PCSK9 is increased in aSAH patients with DCI.The combined application of the two index has a higher predictive performance for the occurrence of DCI after aSAH.
