Neuroprotective Mechanism of Exercise on Alzheimer's Disease:Role of Oxidative Stress
10.13865/j.cnki.cjbmb.2025.02.1403
- VernacularTitle:聚焦氧化应激在运动改善阿尔茨海默病的机制
- Author:
Fan-Xi ZENG
1
;
Ren-Qing ZHAO
1
;
Bin WANG
1
Author Information
1. 扬州大学体育学院,运动人体科学系,江苏扬州 225100
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease(AD);
oxidative stress;
exercise
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(5):687-695
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a neurodegenerative disorder primarily affecting memory,learn-ing,and cognitive functions.It poses a significant health concern for the elderly,but effective treatments are lacking.Its main pathological features are amyloid β(Aβ)deposits forming senile plaques(SPs)and neurofibrillary tangles(NFTs)formed by hyperphosphorylated tau(p-Tau).These pathological changes often induce oxidative stress,which is an important pathological mechanism in AD.Oxidative stress is closely associated with Aβ and Tau deposition and is a potential target for intervention in the treatment of AD.However,the pathological mechanisms leading to AD are multifactorial,and AD oxida-tive stress often interacts with other mechanisms to jointly influence the AD process.Therefore,this paper focuses on the regulatory relationship between mitophagy,neuroinflammation,neuronal apoptosis and nu-clear factor erythroid 2-related factor 2(Nrf2)and oxidative stress.By elucidating the relationship be-tween the pathological features,oxidative stress and its regulatory mechanism of AD,potential effective intervention targets were found.At present,numerous studies have indicated that exercise can alleviate oxidative stress in AD and improve cognitive function,but the underlying molecular mechanisms require further clarification.Therefore,we further discussed the mechanism by which exercise regulates oxidative stress and related molecular signaling pathways,and clarified that exercise may ameliorate AD oxidative stress by affecting these signaling pathways,thereby improving AD-related pathological features and cog-nitive function.It is helpful to understand the pathogenesis of AD from the perspective of molecular mechanism and provide theoretical support for scientific and effective exercise intervention to prevent and cure AD.
