Expression and diagnostic value of long noncoding RNA GUSBP3 and SAM4 in type 2 diabetes mellitus in Kazakh populations in the Xinjiang region of China
10.3969/j.issn.1006-6187.2025.06.001
- VernacularTitle:新疆哈萨克族2型糖尿病外周血中长链非编码RNA GUSBP3和SAM4表达水平及诊断价值的研究
- Author:
Tianshui MA
1
;
Tao BA
1
;
Xiangyun CHANG
1
;
Kan SUN
1
Author Information
1. 832000 石河子大学第一附属医院内分泌代谢科
- Publication Type:Journal Article
- Keywords:
Long noncoding RNA;
Diabetes mellitus,type 2;
Kazakh
- From:
Chinese Journal of Diabetes
2025;33(6):401-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels and diagnostic value of long noncoding RNA(LncRNA)GUSBP3 and LncRNA SAM4 in peripheral blood of Kazakh type 2 diabetes mellitus(T2DM)patients in Xinjiang.Methods From January to September 2019,Kazakh T2DM patients in The First Affiliated Hospital of Shihezi University were recruited through outpatient or inpatient department(T2DM group,n=30).And 30 healthy people were selected as normal control(NC)group during the same period.The general data,biochemical indicators and differentially expressed LncRNA levels were compared between the two groups.Spearman correlation analysis was used to analyze the correlation between the target genes and each index.Logistic regression was used to analyze the influencing factors for T2DM.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of target genes.Results The differentially expressed LncRNA were LncRNA GUSBP3 and LncRNA SAM4 in the two groups.DBP,FPG,HbA1c,fructosamine,FIns,islet β cell function index,serum creatinine(Scr),LncRNA GUSBP3 and LncRNA SAM4 were higher in the T2DM group than in the NC group(P<0.05).Spearman correlation analysis showed that the expression of LncRNA GUSBP3 was positively correlated with Scr and serum uric acid(SUA)(r=0.328,0.322,P<0.05),and negatively correlated with FIns(r=-0.295,P<0.05).The expression of LncRNA SAM4 was positively correlated with SUA(r=0.275,P<0.05)and negatively correlated with LDL-C(r=-0.212,P<0.05).Logistic regression analysis showed that DBP(OR 1.175,95%CI 1.011～1.367),FIns(OR 0.852,95%CI 0.739～0.982),LncRNA GUSBP3(OR 0.378,95%CI 0.149～0.958)was influencing factors for T2DM in Kazakh population.The area under the ROC curve of LncRNA GUSBP3 was 0.789 for T2DM diagnosis.Conclusions The expression levels of LncRNA GUSBP3 and LncRNA SAM4 were higher in Kazakh patients with T2DM than in healthy people,and their expression levels are related to some biochemical indicators.DBP,FIns and LncRNA GUSBP3 are the influencing factors for T2DM in Kazakh population.LncRNA GUSBP3 may be a biomarker for the diagnosis of T2DM in Kazakh in Xinjiang.
