Analysis of Risk Factors Associated with Lymph Node Metastasis in Endome-trial Cancer and Construction of a Predictive Model
10.3969/j.issn.1003-6946.2025.10.016
- VernacularTitle:子宫内膜癌淋巴结转移相关危险因素分析及预测模型的构建
- Author:
Yanhong WU
1
;
Mengli MAO
;
Yutong XIE
;
Yifeng WANG
;
Dongxian PENG
;
Jin YANG
;
Ying MA
;
Honglei ZHU
;
Nana HAN
;
Mingyue ZHU
;
Xiafei FU
Author Information
1. 南方医科大学珠江医院妇产科,广东 广州 510280
- Publication Type:Journal Article
- Keywords:
Endometrial cancer;
Lymph node metastasis;
Inflammatory markers;
Predictive model;
Nomogram
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(10):859-864
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between general demographic characteristics,inflammatory indicators,nutritional indicators,pathological data and lymph node metastasis in endometrial cancer(EC)pa-tients,and to construct and validate a model for preoperative prediction of lymph node status in endometrial canc-er patients.Methods:The preoperative clinical data of 473 patients with EC who underwent surgical treatment in the Zhu Jiang Hospital of Southern Medical University from January 2010 to April 2024 were retrospectively ana-lyzed.The independent risk factors of lymph node metastasis of endometrial cancer were screened by univariate and multivariate Logistic regression analyses,and the nomogram prediction model was constructed by R soft-ware.The performance of the model was evaluated by the receiver operating characteristic(ROC)curve,calibra-tion curve and clinical decision curve.Results:Menopausal status,high grade biopsy pathology,CA125 ≥24.47U/ml,systemic immune inflammatory index(SII)≥710.91,and prognostic nutritional index(PNI)＜52.90 were in-dependent risk factors for lymph node metastasis in endometrial cancer(OR＞1,P＜0.05).The nomogram model constructed based on these five factors had an AUC of 0.853 in the training set and 0.871 in the test set.The cali-bration curve fitted well,and the clinical decision curve shows a positive benefit.Conclusions:The endometrial cancer lymph node metastasis prediction model constructed based on menopausal status,biopsy pathology,CA125,SII,and PNI has good accuracy and fit,with certain clinical application value.
