The research progress of neoadjuvant and conversion therapy in biliary tract carcinoma
10.3760/cma.j.cn112139-20250110-00015
- VernacularTitle:胆道恶性肿瘤新辅助治疗和转化治疗的临床研究进展
- Author:
Chenlu LAN
1
;
Zhiming ZENG
;
Guangzhi ZHU
;
Tao PENG
Author Information
1. 广西医科大学第一附属医院肝胆外科 广西消化道肿瘤加速康复外科基础研究重点实验室 广西医科大学区域性高发肿瘤早期防治研究教育部重点实验室，南宁 530021
- Publication Type:Journal Article
- Keywords:
Biliary tract neoplasms;
Antineoplastic protocols;
Neoadjuvant therapy;
Conversion therapy;
Comprehensive therapy
- From:
Chinese Journal of Surgery
2025;63(10):904-910
- CountryChina
- Language:Chinese
-
Abstract:
Biliary tract carcinoma (BTC) is a highly aggressive malignancy,and the majority of patients present with advanced stage at first diagnosis which resulting in poor prognosis. Traditional chemotherapy and monotherapy have shown limited efficacy in treating BTC. However,with the continuous emergence of clinical research findings and updates to relevant guidelines,there have been some breakthroughs in systemic therapies for BTC. This paper analyzes domestic and international literature on neoadjuvant therapy and conversion therapy for BTC,aiming to provide a reference for clinical research. Overall,research on neoadjuvant therapy and conversion therapy remains in the preliminary exploration phase. Current evidence suggests that combination strategies involving immunotherapy and chemotherapy,with or without targeted therapy,have demonstrated promising clinical efficacy,offering new hope for neoadjuvant therapy and conversion therapy in BTC. Furthermore,the evolution of precision targeted therapies offers better opportunities for personalized treatment,and the combination of local interventions and systemic therapies demonstrates promising therapeutic potential. However,the optimal strategies and timing for surgery of neoadjuvant therapy and conversion therapy have not yet been standardized. Moreover,most studies lack precise designs to address the heterogeneity of BTC,new therapies have not yet reached the ideal stage of personalized treatment,further research is warranted to address these challenges.
