Tumor necrosis factor-α and central mechanism of acute tinnitus
10.3969/j.issn.1006-7299.2025.06.016
- VernacularTitle:肿瘤坏死因子-α与急性耳鸣的中枢机制探讨
- Author:
Zhihui XU
1
;
Yan HUO
1
;
Wenchen LING
1
;
Jianning ZHANG
1
Author Information
1. 上海中医药大学附属岳阳中西医结合医院耳鼻喉科(上海 200437)
- Publication Type:Journal Article
- Keywords:
Tinnitus;
Tumor necrosis factor-α(TNF-a);
Neural plasticity;
Neurotransmitter;
Ca2+
- From:
Journal of Audiology and Speech Pathology
2025;33(6):587-591
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of tinnitus is unclear and may involve the peripheral and central nervous sys-tems.Recent studies have found that neuroinflammatory response leads to hyperactivity of nerve center,in which tumor necrosis factor-α(TNF-α)has an important impact on neurotransmitter transmission,transmembrane ion concentration,neuronal synaptic structure and functional reorganisation,and may play an important role in the path-ogenesis of acute tinnitus.This article discusses the central mechanism of TNF-α in mediating the onset of acute tin-nitus.
