Determination of aluminum in fat emulsion injection by ICP-AES and ICP-MS
10.19778/j.chp.2024.06.014
- VernacularTitle:ICP-AES和ICP-MS测定脂肪乳类注射液中铝元素含量
- Author:
Yu DONG
1
;
Weina KAN
1
;
Zhe ZHAO
1
;
Jiao XUE
1
;
Zhenhong WANG
1
Author Information
1. 辽宁省药品检验检测院,沈阳 110036
- Publication Type:Journal Article
- Keywords:
ICP-MS;
ICP-MS;
fat emulsion injection;
aluminum;
determination of content;
comparative analysis
- From:
Drug Standards of China
2024;25(6):612-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish ICP-AES and ICP-MS methods for determination of aluminum impurities in fat emulsion injection and compare the difference between the two methods.Methods:Compare the linearity,accura-cy,repeatability,detection limit,quantification limit and sample determination results of the two methods by meth-odological verification and determination.Results:The linearity range of two methods were 5-200 μg·L-1,the correlation coefficients were greater than 0.999,the average recovery were 103.0％,106.7％,103.2％(n=9)and 99.8％,106.5％,100.8％(n=9),The RSD of reproducibility both were 2.0％,the detection limit of two methods were 1.22 and 0.36 μg·L-1.The quantification limit of two methods were 4.07 and 1.20 μg·L-1.The contents of aluminum impurities in 8 batches of fat emulsion injection were basically the same.Conclusion:The two methods were convenient,sensitive,accurate and good repeatability,which can be used for the determination of aluminum impurities in fat emulsion injection.
