Study on the relationship between serum uric acid levels and short-term poor prognosis in patients with small artery occlusion stroke
10.3969/j.issn.1004-1648.2024.06.003
- VernacularTitle:小动脉闭塞型卒中患者血尿酸水平与短期预后不良的关系研究
- Author:
Huan CAO
1
;
Hongzhen ZHAI
1
;
Cong ZHAO
1
Author Information
1. 102200 北京市昌平区医院神经内科
- Publication Type:Journal Article
- Keywords:
stroke;
small artery occlusion;
serum uric acid;
short-term poor outcome
- From:
Journal of Clinical Neurology
2024;37(6):406-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum uric acid(SUA)level and short-term poor prognosis in patients with small artery occlusion(SAO)type stroke.Methods Clinical data and 3-month poor prognosis outcomes of patients with SAO type stroke admitted to Changping District Hospital,Beijing,from April 2020 to April 2023 were retrospectively collected.The SUA levels were analyzed both as a continuous variable and as a tertile categorical variable(T1-T3).The relationship between SUA levels and short-term prognosis in SAO type stroke patients was explored using univariate and multivariate Logistic regression analyses.Results A total of 279 patients with SAO type stroke were included in this study.After adjusting for relevant confounding factors,multivariate Logistic regression analysis revealed that for every 10 μmol/L increase in SUA levels,the risk of short-term poor prognosis in SAO type stroke patients decreased by 5％(OR=0.95,95％CI:0.91-0.98,P=0.005).Compared to the T3 group,patients in the T1 group(SUA ≤268 μmol/L)had a 2.54-fold increased risk of short-term poor prognosis(OR=3.54,95％CI:1.34-9.39,P=0.011).Trend analysis showed a statistically significant difference in short-term poor prognosis from the T1 to T3 groups(trend test P=0.008).Based on smooth curve fitting and the distribution of mRS scores among the T1-T3 groups,it was found that the proportion of short-term poor prognosis was significantly lower in the T2 and T1 groups compared to the T3 group.Conclusion Low SUA levels are an independent risk factor for short-term poor prognosis in patients with SAO type stroke.
