Review of the Minimal Clinically Important Difference of EQ-5D-3L Based on Anchor-Based Method
- VernacularTitle:基于效标法测量EQ-5D-3L的最小临床重要差异值述评
- Author:
Yu ZHENG
1
;
Lei DOU
1
;
Shunping LI
1
Author Information
1. 山东大学齐鲁医学院公共卫生学院卫生管理与政策研究中心、国家卫生健康委员会卫生经济与政策研究重点实验室(山东大学)、山东大学健康偏好研究中心 山东 济南 250012
- Publication Type:Journal Article
- Keywords:
Minimal Clinically Important Difference;
Anchor-based Method;
EQ-5D-3L;
review
- From:
Chinese Health Economics
2025;44(8):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To review the Minimal Clinically Important Difference(MCID)of EQ-5D-3L calculated by anchor-based method,evaluate the reliability of existing MCID,and provide reference thresholds for the interpretation of clinical research results.Methods:CNKI,PubMed,Embase and others were searched from inception to June 30,2023.The nonparametric tests were used to analyze the impact of statistical methods and sample size on MCID.Results:A total of 51 studies were eventually included.Studies were primarily prospective in design,32 studies focused on musculoskeletal disorders,37 studies used a single anchor,45 studies adopted patient-perspective anchor,and the Receiver Operating Characteristic(ROC)curve was the main statistical analysis method.A total of 160 MCID were obtained from 51 studies,ranging from 0.003 to 0.540,and only 3 MCID from 2 studies were rated as"high reliability"across all core items of the evaluation instrument.It is found that statistical analysis methods,sample size,and measurement time interval all significantly affect MCID.Conclusion:The disease type in EQ-5D-3L MCID studies were not abundant and unbalanced,and the heterogeneity of MCID measured in the included studies was high.The reliability evaluation results showed that the existing MCID has poor reliability in all items except the first and second items of the evaluation instrument.
