Correlation of characteristics of symptomatic middle cerebral artery plaques with risk of stroke recurrence:Study based on high-resolution vessel wall imaging
10.19745/j.1003-8868.2025030
- VernacularTitle:基于高分辨磁共振血管壁成像的症状性大脑中动脉粥样硬化斑块特征与脑卒中复发风险关系研究
- Author:
Xing-xing ZENG
1
;
Li-rong WANG
;
Zhi-guo GAO
;
Jin-fei LU
;
Xiao-li JIANG
;
Xiao-yi LI
Author Information
1. 宜昌市中心人民医院神经内科,湖北宜昌 443003
- Publication Type:Journal Article
- Keywords:
stroke;
high resolution vessel wall imaging;
middle cerebral artery;
atherosclerosis;
plaque characteristic;
stroke recurrence
- From:
Chinese Medical Equipment Journal
2025;46(2):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of the characteristics of symptomatic middle cerebral artery plaques with the risk of stroke recurrence based on high-resolution vessel wall imaging(HR-VWI).Methods Totally 83 patients hospitalized for acute ischemic stroke(AIS)and transient ischemic attack(TIA)at Jingmen People's Hospital and Yichang Central People's Hospital from January 2019 to August 2022 were selected prospectively,who all underwent the treatment with antiplatelet aggregation and intensive lipid lowering by statins.During the follow-up,AIS or TIA recurrences were determined in case of newly found symptoms of neurological impairment in the same supply area of the responsible vessel or new infarct foci confirmed by cranial diffusion weighted imaging(DWI).The patients with AIS or TIA recurrences were enrolled into a recurrence group,and the remained ones were divided into a non-recurrence group.The recurrence group went through HR-VWI scanning within two weeks of recurrence and statin treatment,and the non-recurrence group was examined with HR-VWI half a year after receiving statin treatment.All the patients had their clinical indexes compared before and after statin treatment,the baseline data of the two groups underwent univariate analysis,and Logistic regression analysis was performed for the high-risk factors related to recurrence.SPSS 22.0 software was used for statistical analysis.Results After six months of statin treatment,all the patients were improved in TC,TG,luminal stenosis rate,high T1WI signal,plaque burden,plaque enhancement rate and NIHSS score,with the differences being significant(all P＜0.05).Univariate analysis showed the recurrence group had higher plaque enhancement rates(P=0.012)and higher plaque burden(P=0.047)when compared with the non-recurrence group,with the differences being significant;the two groups were not statistically different in luminal stenosis rate,high T1WI signal,plaque thickness and remodeling index(all P＞0.05).Multivariate logistic regression analysis indicated the plaque enhancement rate was independently correlated with stroke recurrence within 6 months(P=0.027).Conclusion HR-VWI can effectively assess MCA plaque characteristics in recurrent stroke patients,and high plaque enhancement rate faciliates the evaluation of stroke recurrence.[Chinese Medical Equipment Journal,2025,46(2):63-67]
