Current status and prospects of surgical treatment for adenocarcinoma of the esophagogastric junction
10.3760/cma.j.cn112139-20250314-00129
- VernacularTitle:食管胃结合部腺癌的外科治疗现状与展望
- Author:
Zhe XUAN
1
;
Linjun WANG
1
;
Zekuan XU
1
Author Information
1. 南京医科大学第一附属医院普通外科 胃肿瘤中心，南京 210029
- Publication Type:Journal Article
- Keywords:
Surgical procedures, operative;
Stomach neoplasms;
Adenocarcinoma of the esophagogastric junction;
Surgical approach;
Lymph node dissection;
Digestive trac
- From:
Chinese Journal of Surgery
2025;63(7):568-574
- CountryChina
- Language:Chinese
-
Abstract:
Adenocarcinoma of the esophagogastric junction (AEG) has shown an increasing incidence in recent years. The treatment strategy for AEG differs from that of gastric and esophageal cancers due to its unique anatomical location and biological behavior. Surgical resection remains the cornerstone of AEG treatment, with the choice of surgical approach based on Siewert classification, esophageal invasion length, and individual patient factors. The extent of lymph node dissection is determined by tumor location, stage, and patterns of lymph node metastasis. Digestive tract reconstruction aims to maximize the preservation of digestive function and reduce postoperative complications while achieving radical tumor resection. In recent years, minimally invasive surgical techniques, including laparoscopic and robotic surgery, have been increasingly applied in AEG treatment, with preliminary validation of their safety and feasibility. Additionally, the application of neoadjuvant therapy, targeted therapy, and immunotherapy has brought new hope for AEG treatment. This article reviews the current status of surgical treatment for AEG, including surgical approaches, lymph node dissection, digestive tract reconstruction, and neoadjuvant therapy, and discusses future directions in AEG surgical treatment.
