Progress in the study of the surgical management of Crohn disease based on the mesenteric concept
10.3760/cma.j.cn112139-20240331-00155
- VernacularTitle:基于肠系膜理念的克罗恩病外科治疗的研究进展
- Author:
Ping LAN
1
;
Zongjin ZHANG
1
;
Zhen HE
1
Author Information
1. 中山大学附属第六医院普通外科（结直肠外科）广东省结直肠盆底疾病研究重点实验室 广州市黄埔区中六生物医学创新研究院 人体微生态与老年慢性疾病教育部重点实验室，广州 510655
- Publication Type:Journal Article
- Keywords:
Crohn disease;
Mesentery;
Extended mesenteric resection;
Kono-S anastomosis;
Postoperative recurrence
- From:
Chinese Journal of Surgery
2025;63(2):107-113
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the deepening of mesentery research, it is found that its blood vessels, nerves, lymphoid tissue, adipose tissue and other structures play an important role in the occurrence and development of Crohn disease, and the degree of lesion is related with the disease process, surgical difficulty, the occurrence of intraoperative complications and postoperative recurrence. The optimal surgical strategy of Crohn disease based on mesenteric involvement has received great attention. Multiple retrospective studies found that extended mesenteric resection and Kono-S anastomosis potentially could reduce the rate of postoperative recurrence. However, the latest prospective randomized controlled studies did not achieve the expected results, and the evidence for the surgical strategy based on mesentery is still weak. This review summarises the findings of basic and clinical investigations of the mesentery in Crohn disease so far and explores its role in surgical treatment optimization, and provides new thinking and insights for the further research and surgical options for Crohn disease.
