Correlation between MRI burden of cerebral small vessel disease and cognitive impairment in elderly hypertensive people
10.3969/j.issn.1002-0152.2025.01.003
- VernacularTitle:脑小血管病MRI总负荷与老年高血压群体认知功能障碍的相关性分析
- Author:
Jie LI
1
;
Linyi JIA
;
Fengxiao GAO
;
Wensheng WANG
;
Bingxin PANG
Author Information
1. 河北医科大学附属邢台市人民医院神经内四科(邢台 054001)
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Hypertension;
Magnetic resonance imaging;
MRI total burden;
Cogni-tive impairment
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(1):15-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the correlation between MRI burden of cerebral small vessel disease and cognitive impairment in elderly hypertensive people.Methods Data of elderly hypertensive people with CSVD at Xingtai People's Hospital Affiliated to Hebei Medical University from January 2018 to September 2024 were analyzed.According to the total MRI burden score,patients were divided into mild to moderate(0-2)and severe(3-4)burden groups.The baseline data and cognitive impairment were compared between groups.The correlation between risk factors of MRI burden and cognitive impairment was analyzed.Results The severe burden group had higher systolic blood pressure[178(155,180)mmHg vs.159.50(147.75,170)mmHg,higher fasting blood glucose[5.70(5.37,5.92)mmHg vs.5.38(4.83,5.70)mmHg,P<0.05]and higher the proportion of cognitive impairment[8(28.1%)vs.3(6.8%),P<0.05]than the mild to moderate group.Multivariate logistic regression analysis revealed that systolic blood pressure(OR=1.033,95%CI:1.001-1.067,P<0.05)was the independent risk factor for total MRI burden.Spearman correlation analysis revealed that MRI total burden was negatively correlated with MMSE score(r=-0.315,P=0.011)and MoCA score(r=-0.662,P<0.001).Compared with the mild to moderate burden group,the severe group performed worse in the areas of orientation,attention and computation,language ability on the MMSE,and worse in visual space and executive ability,attention,language,delayed recall,and orientation on the MoCA(P<0.05).Conclusion Systolic blood pressure is the independent risk factor of MRI total burden in elderly hypertensive people.The higher the total MRI burden,the more severe the cognitive impairment,the worse performance in orientation,visual space and executive ability,attention and computation,language,and delayed recall.
