Changes of intestinal flora in patients with type 2 diabetes mellitus complicated with coronary heart disease after liraglutide treatment and its correlation with glucose and lipid metabolism indexes
10.12092/j.issn.1009-2501.2025.08.009
- VernacularTitle:利拉鲁肽治疗后2型糖尿病合并冠心病患者肠道菌群变化及其与糖、脂代谢指标相关性
- Author:
Ying XING
1
;
Rongjiong ZHENG
1
;
Chunhui JIANG
1
;
MAYILA·KAHAER
1
;
MUHUYATI·WULASIHAN
1
Author Information
1. 新疆医科大学第一附属医院综合内四科,乌鲁木齐 830000,新疆
- Publication Type:Journal Article
- Keywords:
type 2 diabetes;
coronary heart dis-ease;
intestinal flora;
liraglutide
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(8):1084-1091
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the changes of intesti-nal flora in patients with type 2 diabetes mellitus complicated with coronary heart disease after lira-glutide treatment and its correlation with glucose and lipid metabolism indexes.METHODS:Twenty-six patients with type 2 diabetes mellitus complicat-ed with coronary heart disease were selected to compare the changes of glucose and lipid metabo-lism indexes and intestinal flora(high-throughput sequencing technique)before and after liraglutide treatment,and to analyze the correlation between glucose and lipid metabolism indexes and intestinal flora.RESULTS:Compared with those before treat-ment,the indexes of glucose metabolism and lipid metabolism in the patients were significantly de-creased(P＜0.01).Liraglutide had no significant ef-fect on the diversity of intestinal flora(P＞0.05),but can significantly change the composition of intesti-nal flora(P＜0.05).While beneficial bacteria such as Lachnospiraceae increased significantly,it signifi-cantly reduced the abundance of pathogenic bacte-ria such as Escherichia_Shigella(P＜0.05),and pro-moted the production of short-chain fatty acids and body metabolism.CONCLUSION:Lilalutide can affect the composition of intestinal flora in type 2 diabetes patients with coronary heart disease,and then participate in the regulation of glucose and lipid metabolism.
