Changing distribution and antibiotic resistance profiles of the respiratory bacterial isolates in hospitals across China:data from CHINET Antimicrobial Resistance Surveillance Program,2015-2021
- VernacularTitle:2015-2021年CHINET呼吸道临床分离菌菌种分布及耐药性变迁
- Author:
Ying FU
1
;
Yunsong YU
;
Jie LIN
;
Yang YANG
;
Fupin HU
;
Demei ZHU
;
Yingchun XU
;
Xiaojiang ZHANG
;
Fengbo ZHANG
;
Ping JI
;
Yi XIE
;
Mei KANG
;
Chuanqing WANG
;
Pan FU
;
Yuanhong XU
;
Ying HUANG
;
Ziyong SUN
;
Zhongju CHEN
;
Yuxing NI
;
Jingyong SUN
;
Yunzhuo CHU
;
Sufei TIAN
;
Zhidong HU
;
Jin LI
;
Bin SHAN
;
Yan DU
;
Sufang GUO
;
Lianhua WEI
;
Fengmei ZOU
;
Hong ZHANG
;
Chun WANG
;
Yunjian HU
;
Xiaoman AI
;
Chao ZHUO
;
Danhong SU
;
Dawen GUO
;
Jinying ZHAO
;
Hua YU
;
Xiangning HUANG
;
Wen'en LIU
;
Yanming LI
;
Yan JIN
;
Chunhong SHAO
;
Xuesong XU
;
Chao YAN
;
Shanmei WANG
;
Yafei CHU
;
Lixia ZHANG
;
Juan MA
;
Shuping ZHOU
;
Yan ZHOU
;
Lei ZHU
;
Jinhua MENG
;
Fang DONG
;
Zhiyong LÜ
;
Fangfang HU
;
Han SHEN
;
Wanqing ZHOU
;
Wei JIA
;
Gang LI
;
Jinsong WU
;
Yuemei LU
;
Jihong LI
;
Jinju DUAN
;
Jianbang KANG
;
Xiaobo MA
;
Yanping ZHENG
;
Ruyi GUO
;
Yan ZHU
;
Yunsheng CHEN
;
Qing MENG
;
Shifu WANG
;
Xuefei HU
;
Jilu SHEN
;
Ruizhong WANG
;
Hua FANG
;
Bixia YU
;
Yong ZHAO
;
Ping GONG
;
Kaizhen WENG
;
Yirong ZHANG
;
Jiangshan LIU
;
Longfeng LIAO
;
Hongqin GU
;
Lin JIANG
;
Wen HE
;
Shunhong XUE
;
Jiao FENG
;
Chunlei YUE
;
Wenhui HUANG
Author Information
- Publication Type:Journal Article
- Keywords: antimicrobial resistance surveillance; respiratory tract; antimicrobial susceptibility testing; antimicrobial agent; changing resistance
- From: Chinese Journal of Infection and Chemotherapy 2025;25(4):431-444
- CountryChina
- Language:Chinese
- Abstract: Objective To characterize the changing species distribution and antibiotic resistance profiles of respiratory isolates in hospitals participating in the CHINET Antimicrobial Resistance Surveillance Program from 2015 to 2021.Methods Commercial automated antimicrobial susceptibility testing systems and disk diffusion method were used to test the susceptibility of respiratory bacterial isolates to antimicrobial agents following the standardized technical protocol established by the CHINET program.Results A total of 589 746 respiratory isolates were collected from 2015 to 2021.Overall,82.6％of the isolates were Gram-negative bacteria and 17.4％were Gram-positive bacteria.The bacterial isolates from outpatients and inpatients accounted for(6.0±0.9)％and(94.0±0.1)％,respectively.The top microorganisms were Klebsiella spp.,Acinetobacter spp.,Pseudomonas aeruginosa,Staphylococcus aureus,Haemophilus spp.,Stenotrophomonas maltophilia,Escherichia coli,and Streptococcus pneumoniae.Each microorganism was isolated from significantly more males than from females(P＜0.05).The overall prevalence of methicillin-resistant S.aureus(MRSA)was 39.9％.The prevalence of penicillin-resistant S.pneumoniae was 1.4％.The prevalence of extended-spectrum β-lactamase(ESBL)-producing E.coli and K.pneumoniae was 67.8％and 41.3％,respectively.The overall prevalence of carbapenem-resistant E.coli,K.pneumoniae,Enterobacter cloacae,Pseudomonas aeruginosa,and Acinetobacter baumannii was 3.7％,20.8％,9.4％,29.8％,and 73.3％,respectively.The prevalence of β-lactamase was 96.1％in Moraxella catarrhalis and 60.0％in Haemophilus influenzae.The H.influenzae isolates from children(＜18 years)showed significantly higher resistance rates to β-lactam antibiotics than the isolates from adults(P＜0.05).Conclusions Gram-negative bacteria are still predominant in respiratory isolates associated with serious antibiotic resistance.Antimicrobial resistance surveillance should be strengthened in clinical practice to support accurate etiological diagnosis and appropriate antimicrobial therapy based on antimicrobial susceptibility testing results.
