Profiling of risk factors for and prognosis of brucellar spondylitis
10.16718/j.1009-7708.2025.04.004
- VernacularTitle:布鲁菌脊柱炎危险因素及预后分析
- Author:
Tongtong SHEN
1
;
Jing KUANG
1
;
Yiran YAN
1
;
Shuangqin TENG
1
;
Wei WANG
1
;
Yadong WANG
1
;
Caiyan ZHAO
1
Author Information
1. 河北医科大学第三医院感染科,石家庄 050051
- Publication Type:Journal Article
- Keywords:
brucellosis;
brucellar spondylitis;
risk factor;
prognostic factor
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(4):376-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to examine the risk factors and prognostic factors of brucellar spondylitis for early prevention and treatment of the disease,and improving the outcomes of patients.Methods A retrospective case-control study was conducted on the patients with brucellosis who were hospitalized in the Third Hospital of Hebei Medical University from June 2020 to June 2022.Patients were assigned to brucellosis without spondylitis group or brucellar spondylitis group according to the presence of spondylitis.The patients in brucellar spondylitis group were followed for 1 year.Then they were stratified into a subgroup of good or poor prognosis according to clinical outcomes.The dataset for the demographic and clinical variables of patients were analyzed using SPSS 26.0 software.Results A total of 300 patients with brucellosis were enrolled,including 113 cases of brucellosis without spondylitis and 187 cases of brucellar spondylitis.Multivariate analysis showed that age,time from onset to diagnosis,low back pain,and erythrocyte sedimentation rate were independent risk factors for brucellar spondylitis(P＜0.05).Of the 154 cases of brucellar spondylitis with known outcomes,121 cases showed good prognosis and 33 cases had poor prognosis.COX regression analysis showed that the time from onset to diagnosis,diabetes mellitus,paravertebral abscess,and neurological impairment were independent risk factors for poor prognosis in patients with brucellar spondylitis(P＜0.05).Conclusions Old age,prolonged time from onset to diagnosis,low back pain,and increased erythrocyte sedimentation rate are independent risk factors for spondylitis in patients with brucellosis.Prolonged time from onset to diagnosis,diabetes mellitus,paravertebral abscess,and neurological impairment are independent risk factors for poor prognosis of brucellar spondylitis.
