Clinical characteristics and prognostic factors of 233 cases of Staphylococcus aureus bacteremia in adult patients
10.16718/j.1009-7708.2025.04.002
- VernacularTitle:成人金黄色葡萄球菌血流感染233例的临床特征及预后影响因素
- Author:
Yufang CHEN
1
;
Chaoyan YAN
1
;
Shuangqing LIAN
1
;
Lijun QIU
1
;
Yanyi GUO
1
;
Yanqing ZHANG
1
;
Xuan LIN
1
Author Information
1. 福州大学附属省立医院医院感染管理与疾病预防控制处,福州 350001
- Publication Type:Journal Article
- Keywords:
Staphylococcus aureus;
bacteremia;
clinical feature;
prognosis;
risk factor
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(4):364-370
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and prognostic factors of Staphylococcus aureus bloodstream infections in adult patients for improving clinical treatment and identifying potential interventions.Methods Clinical data of inpatients diagnosed with S.aureus bloodstream infection confirmed by blood culture in a hospital from January 2016 to December 2023 were retrospectively reviewed.The data included patient age,gender,history of hospital admission,department of admission,underlying diseases,primary infection,quick Pitt bacteremia score(qPitt),invasive treatment,empirical anti-infective treatment,and treatment outcomes.Patients were assigned to case group or control group according to whether they died in hospital in order to identify the prognostic factors of patient outcomes.Binary logistic regression analysis was used to identify independent prognostic factors.Results A total of 233 cases of S.aureus bacteremia were identified.Multivariate logistic regression analysis showed that age ≥ 70 years old(OR=4.725,95％CI:1.228-18.173,P=0.024),diabetes mellitus(OR=8.161,95％CI:1.954-34.086,P=0.004),Charlson comorbidity index(CCI)≥ 5(OR=7.672,95％CI:1.901-30.963,P=0.004),hospital infection(OR=7.853,95％CI:1.588-38.832,P=0.012),and qPitt ≥ 2(OR=23.189,95％CI:4.461-120.552,P＜0.001)were independent prognostic factors for poor outcome of patients with S.aureus bacteremia,while catheter-associated infection(OR=0.051,95％CI:0.005-0.579,P=0.016)was negatively correlated with mortality.Conclusions Advanced age,diabetes mellitus,high CCI,hospital infection,and high qPitt were independent prognostic factors for poor outcomes of patients with S.aureus bacteremia.The patients should be well managed by timely removal of eradicable lesions to improve patient outcomes.
