Current status and progress of ALPPS

VernacularTitle:ALPPS的研究现状与进展
Author: Jian ZHOU ¹ ; Yuanfei PENG ¹
Author Information

1. 复旦大学附属中山医院肝肿瘤外科　复旦大学肝癌研究所，上海　200032
Publication Type:Journal Article
Keywords: Liver neoplasms; Surgical procedures, operative; Future liver remnant; Associating liver partition and portal vein ligation for staged hepatectomy
From: Chinese Journal of Surgery 2025;63(4):265-270
CountryChina
Language:Chinese
Abstract: Surgical resection is the mainstay of curative treatment for long-term survival of patients with liver cancer. However, many patients are excluded for surgical resection due to insufficient future liver remnant(FLR). The two-stage hepatectomy (induction of FLR hypertrophy followed by tumor resection) is one of the main treatment strategies for insufficient FLR. The new associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an important innovative procedure for inducing FLR hypertrophy, which has the advantages of rapid and significant induction of FLR hypertrophy as well as high tumor resection rate, but it was controversial in the early years due to high postoperative morbidity and mortality. After more than 10 years of development, ALPPS has made tremendous advance. Surgical safety of ALPPS has been significantly improved, and oncological benefits and other issues have been largely clarified. This article aims to introduce the current status and progress of ALPPS.