Necessity and significance in basic and clinical research of liver xenotransplantation
10.3760/cma.j.cn112139-20241206-00557
- VernacularTitle:异种肝移植的基础与临床研究任重道远
- Author:
Xin HONG
1
;
Xuan ZHANG
1
;
Kefeng DOU
1
Author Information
1. 空军军医大学第一附属医院肝胆外科，西安 710032
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Therapies, investigational;
Basic research;
Donor liver shortage;
Liver xenotransplantation
- From:
Chinese Journal of Surgery
2025;63(4):294-299
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is the only effective cure for end-stage liver disease. However,donor liver shortage has become a major problem,limiting the development of liver transplantation. Among the many ways to solve the problem of donor liver shortage,xenotransplantation has high feasibility and prospect of clinical application. In recent years,heart and kidney xenotransplantation have been successfully carried out in clinical trials,while there are few studies on liver xenotransplantation. The survival time of preclinical models in liver xenotransplantation is limited to 34 days,which is not sufficient for clinical trials. The future clinical trials of liver xenotransplantation will face multiple challenges such as immune rejection,interspecific incompatibility,social and ethical issues,which require the joint efforts of government,society,research institution and medical institution and to promote the basic and clinical research of liver xenotransplantation in China.
