A retrospective analysis of 107 cases of hematologic disease complicated with candidemia
10.16718/j.1009-7708.2025.04.003
- VernacularTitle:血液病患者合并念珠菌血症107例
- Author:
Lina GUAN
1
;
Weijie CAO
;
Yanliang BAI
;
Quande LIN
;
Shuxia GUO
Author Information
1. 河南中医药大学第五临床医学院(郑州人民医院)血液科,郑州 450003
- Publication Type:Journal Article
- Keywords:
hematological disease;
candidemia;
pathogen;
antimicrobial resistance;
risk factor
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(4):371-375
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features,etiological features and prognosis of patients with hematologic diseases complicated with candidemia for improving clinical diagnosis and treatment.Methods A retrospective analysis was conducted for 107 hematological patients complicated with candidemia who were treated in the First Affiliated Hospital of Zhengzhou University,Henan Cancer Hospital,Henan Provincial People's Hospital,or Zhengzhou People's Hospital from June 2022 to May 2024.The clinical data and pathogenic bacteria were analyzed by univariate and multivariate analyses.Results The Candida pathogen of the 107 cases of candidemia were mostly Candida tropicalis(73.8％),followed by Candida parapsilosis,Candida glabrata,and Candida albicans.Antifungal susceptibility testing showed that 43.9％,47.7％,and 48.6％of the Candida strains were resistant voriconazole,fluconazole and itraconazole,respectively.Logistic regression analysis found that disease not in remission(OR=7.795,95％CI:2.274-26.723),septic shock(OR=10.376,95％CI:1.129-95.388),multiple organ dysfunction syndrome(MODS)(OR=9.107,95％CI:1.789-46.361),and inappropriate antifungal treatment(OR=3.422,95％CI:1.153-10.153)were risk factors for 30-day mortality in hematological patients with candidemia.Conclusions Candidemia in patients with hematological diseases is associated with high mortality rate,the major pathogen of which is Candida tropicalis.The Candida isolates showed high resistance rates to azoles.Disease not in remission,septic shock,MODS,and inappropriate antifungal treatment are the risk factors for mortality.
