Pathological mechanism and prevention and treatment strategies of"inflammation-cancer transformation"in chronic gastritis from the weakness of the middle jiao and blood stasis
10.3969/j.issn.1006-2157.2025.07.012
- VernacularTitle:从中虚血积探讨慢性胃炎"炎癌转化"的病理机制及防治思路
- Author:
Zhi YANG
1
;
Yandong WEN
;
Zhongyu LI
;
Yibing TIAN
;
Wentong GE
;
Xiaofan ZHAO
;
Chang LIU
Author Information
1. 中国中医科学院西苑医院 北京 100091
- Publication Type:Journal Article
- Keywords:
weakness of the middle jiao and blood stasis;
chronic gastritis;
inflammation-cancer transformation;
gastric precancerous lesion
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(7):973-978
- CountryChina
- Language:Chinese
-
Abstract:
Chronic gastritis is a chronic inflammation of the gastric mucosa caused by various etiologies and can be categorized into chronic non-atrophic gastritis and chronic atrophic gastritis.Chronic atrophic gastritis is a common disorder of the digestive system characterized by gastric mucosal gland atrophy,mucosal thinning,and basal layer thickening.The development of intestinal metaplasia and atypical hyperplasia on this basis is recognized as a precancerous lesion of gastric cancer and represents a key stage in the"inflammation-cancer transformation"of chronic gastritis.However,universally recognized and effective treatment strategies for this"inflammation-cancer transformation"process are lacking in clinical practice.This study integrates Correa′s cascade reaction with clinical practice,summarizing the pathogenesis of the"inflammation-cancer transformation"of chronic gastritis as weakness of the middle jiao and blood stasis.It suggests that the"inflammation-cancer transformation"process involves the pathological development of spleen and stomach deficiency,transportation and transformation dysfunction,turbid phlegm,blood stasis,and the gradual formation of cancerous toxins,with spleen and stomach weakness as the core mechanism and phlegm and blood stasis as the crucial pathological link.Based on an in-depth exploration of the deficiency of the middle jiao and blood stasis,supported by pharmacological research and clinical experience,this paper proposes the therapeutic approach of strengthening the spleen and replenishing qi,expelling phlegm and activating blood.It discusses the related prescriptions in preventing and treating the"inflammation-cancer transformation"of chronic gastritis.This study aims to provide new perspectives and insights for the prevention and treatment of chronic gastritis with traditional Chinese medicine,offering a novel framework for clinical treatment.
