Research advances in villitis of unknown etiology in placenta

VernacularTitle:胎盘病因不明绒毛炎的研究进展
Author: Qian LI ¹ ; Juan LI ; Qiuhong YANG ; Chengquan ZHAO ; Yue WANG ; Fengchun GAO
Author Information

1. 山东第一医科大学附属济南妇幼保健院病理科，济南　250001
Publication Type:Journal Article
Keywords: Villitis of unknown etiology; Pathogenesis; Pregnancy complications; Pathological diagnosis; Therapeutic strategies
From: Chinese Journal of Perinatal Medicine 2025;28(11):989-994
CountryChina
Language:Chinese
Abstract: Villitis of unknown etiology (VUE) occurs in up to 15% of term placentas. Patients with VUE exhibit increased incidence of gestational diabetes mellitus, gestational hypertension, and preeclampsia, with demonstrated recurrence risk. VUE contributes to various adverse pregnancy outcomes. Its pathogenesis involves abnormal maternal immune responses against fetal allografts and may relate to unidentified microbial infections. Currently, VUE diagnosis relies exclusively on placental pathological examination. Clinical management remains primarily symptomatic, though immunomodulatory therapies show potential. This review summarizes recent advances in VUE epidemiology, pathogenesis, clinical significance, pathological features, and preventive strategies, aiming to enhance clinical understanding of this condition.