Research advances on association between placental structural/functional abnormalities and congenital heart disease
10.3760/cma.j.cn113903-20250428-00223
- VernacularTitle:胎盘结构或功能异常与先天性心脏病关联性的研究进展
- Author:
Haihui WANG
1
;
Yue LIANG
;
Jingjing WANG
;
Ranran LANG
;
Jie DONG
;
Xiaohong WANG
Author Information
1. 空军军医大学基础医学院五大队，西安 710032
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
Placenta;
Placenta-heart axis
- From:
Chinese Journal of Perinatal Medicine
2025;28(11):995-999
- CountryChina
- Language:Chinese
-
Abstract:
Congenital heart disease (CHD) may result from various risk factors including genetic, epigenetic, and environmental elements. The parallel and synchronous development of the placenta and fetal heart establishes a regulatory relationship known as the placenta-heart axis. Placental insufficiency may impact fetal cardiac development, while abnormal cardiac development can conversely disrupt placental structure and function. This review examines the association between placental abnormalities and CHD, providing insights into the etiology and underlying mechanisms of CHD.
