Characteristics and research advances in hemolytic disease of the fetus and newborn caused by anti-M antibodies

VernacularTitle:抗M所致胎儿及新生儿溶血病的特点及研究进展
Author: Xiaojing ZHENG ¹ ; Xiulan HAO ; Qun FANG
Author Information

1. 中山大学附属第七医院（深圳）妇产科，深圳　518107
Publication Type:Journal Article
Keywords: Hemolytic disease of the fetus and newborn; MNS blood group system; Anti-M antibodies; Maternal-fetal alloimmunization
From: Chinese Journal of Perinatal Medicine 2025;28(11):1000-1003
CountryChina
Language:Chinese
Abstract: Red cell alloimmunization represents the primary cause of hemolytic disease of the fetus and newborn (HDFN). With advancing clinical management of ABO and Rh alloimmunization, non-Rh alloimmunization has garnered increasing attention. Although MNS system alloimmunization remains rare, reported cases have gradually increased in recent years, particularly in East Asia. Current clinical practice still lacks standardized management protocols for MNS alloimmunization, especially HDFN caused by IgG anti-M antibodies. This review synthesizes recent global research advances in anti-M-mediated HDFN, particularly fetal hemolytic disease, summarizing the unique characteristics of anti-M alloimmunization to inform clinical management strategies for MNS system incompatibility.