Correlation between serum CTRP12 and carotid atherosclerosis in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.02.006
- VernacularTitle:2型糖尿病患者血清C1q/肿瘤坏死因子相关蛋白12水平与颈动脉粥样硬化相关性的研究
- Author:
Xiaoling ZHANG
1
;
Yingzhi HUANG
Author Information
1. 235000 淮北,濉溪县医院内分泌科
- Publication Type:Journal Article
- Keywords:
CTRP12;
Diabetes mellitus,type 2;
Carotid atherosclerosis;
Adipocytokine
- From:
Chinese Journal of Diabetes
2025;33(2):109-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the correlation between serum CTRP12 and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 200 T2DM patients from Bengbu Medical University Third Affilated Hospital were enrolled in this study and divided into T2DM group(n=94),CAS group(n=106).Healthy subjects were selected as normal control(NC,n=50)group.Serum CTRP12 level was determined by ELISA.CTRP12 and baseline indicators were compared among the groups.Relationship between CTRP12 and each biochemical index were evaluated by Pearson or Spearman analysis as appropriate.Multiple linear regression analysis was used to explore the influencing factors for CTRP12.Logistic regression analysis was used to explore the influencing factors for CAS.Results DBP,HbA1c,TC,LDL-C and IL-6 in the three groups were increased successively(P<0.05),while CTRP12 were decreased successively(P<0.05).BMI,FPG,TG and HOMA-IR in T2DM and CAS groups were higher than those in NC group(P<0.05),HDL-C was lower than that in NC group(P<0.05),SBP in CAS group was higher than that in NC and T2DM groups(P<0.05).Pearson or Spearman correlation analysis showed that serum CTRP12 was negatively correlated with BMI,SBP,DBP,FPG,HbA1c,TC,TG,LDL-C,IL-6 and HOMA-IR(P<0.05),and positively correlated with HDL-C(P<0.05).Multiple linear regression analysis showed that FPG,LDL-C and IL-6 were the influential factors for CTRP12.Logistic regression analysis showed that TC,HbA1c and CTRP12 were risk factors for the occurrence of CAS in patients with T2DM.Conclusions CTRP12 is closely related to CAS,and reduced serum CTRP12 level is an independent risk factor for T2DM with CAS.
