Correlation between serum residual cholesterol level and the expression of lipoprotein-associated phospholipase A2 with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.02.005
- VernacularTitle:2型糖尿病患者血清残余胆固醇与脂蛋白相关磷脂酶A2表达相关性的研究
- Author:
Xiaoyan WANG
1
;
Qingshan SHI
;
Quan YE
Author Information
1. 266300 青岛,同济大学附属东方医院胶州医院检验科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Residual cholesterol;
Lipoprotein-associated phospholipase A2;
Macrovascular lesions
- From:
Chinese Journal of Diabetes
2025;33(2):104-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between residual cholesterol(RC)and lipoprotein-associated phospholipase A2(Lp-PLA2)in type 2 diabetes mellitus(T2DM).Methods A total of 362 T2DM patients visited our hospital from January 2022 to June 2023 were divided into RC≥0.78 mmol/L(HRC,n=196)group and RC<0.78 mmol/L(NRC,n=166)group based on the levels of RC.The clinical characteristics and related factors were compared between the two groups and the risk factors for RC were analyzed.Results Compared with NRC group,DM duration,SBP,DBP,TC,TG,rate of ACEI or ARBs use,non-HDL-C,Lp-PLA2 and IMT in HRC group increased(P<0.05)and LDL-C decreased(P<0.05).Pearson and Spearman correlation analysis showed that RC was positively correlated with age,DM duration,SBP,DBP,TC,TG,non-HDL-C,Lp-PLA2,IMT(P<0.05)and negatively correlated with LDL-C(P<0.05).Logistic multivariate regression analysis showed that TC,TG,LDL-C,non-HDL-C,Lp-PLA2 and IMT were the influencing factors of RC in T2DM patients.Receiver operating characteristic curve analysis showed that the cutoff value of RC was 0.85 mmol/L,and the cutoff value of Lp-PLA2 was 242 U/L.The predicted AUC of T2DM macroangiopathy respectively was 0.864 and 0.721,and the predicted AUC of RC combined with Lp-PLA2 was 0.896.Conclusions Serum RC is positively correlated with Lp-PLA2 in T2DM patients.The combined detection of these two indicators has a certain predictive value for T2DM macrovascular disease.
