Application of Nanocarriers in the Delivery of Anticancer Peptides
10.13865/j.cnki.cjbmb.2025.03.1461
- VernacularTitle:纳米载体在抗癌肽递送中的应用
- Author:
Can QIN
1
;
Ai-Ling LIANG
;
Yong-Jun LIU
Author Information
1. 广东医科大学医学技术学院,广东东莞 523808
- Publication Type:Journal Article
- Keywords:
anti-cancer peptides(ACPs);
nanocarriers;
drug delivery
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(6):833-842
- CountryChina
- Language:Chinese
-
Abstract:
The rise of nanomedicine has opened up new avenues for drug delivery and tumor treatment.Nanocarriers,in particular,have become core tools in the field of drug delivery.Anti-cancer peptides(ACPs)can achieve anti-tumor effects by inducing tumor cell apoptosis,inhibiting angiogenesis,and regulating the immune microenvironment.Their low toxic side effects and drug resistance make them im-portant in the field of cancer treatment.However,ACPs face limitations such as poor stability,short in vivo half-life,and low targeted delivery efficiency,which seriously limit their therapeutic effects and fur-ther development.Nanocarriers provide an efficient,flexible and precise solution for the delivery of ACPs due to their advantages of increasing drug solubility,changing drug distribution in the body and improving drug targeting.This review systematically summarizes the structural characteristics and biological proper-ties of four types of nanocarriers,including liposome nanocarriers,polymer nanocarriers,inorganic nano-carriers,and self-assembled peptides,and focuses on analyzing the application examples of nanocarriers in enhancing the stability of ACPs,improving targeted delivery efficiency,improving bioavailability,and overcoming drug-resistant tumor treatment.We also summarize in detail the structural pros and cons of these four carriers.Finally,we look forward to the development direction of research on the combination of nanocarriers and ACPs,in order to provide a theoretical basis for the clinical application of ACPs.
